In healthy individuals, venous blood flows mainly from the superficial veins (located right under the skin) to the deep veins, through the muscles. Once in the deep veins, the blood moves up to the heart and the lungs to be re-oxygenated.
In order to direct the blood flow from the foot to the upper leg, and to prevent it from falling back, the leg veins have thin valves that work as a lock system. Thus, they play a major role in the blood return. Defective valves are mainly responsible for the development of venous disease.