Study aim & design
The aim of this study was to assess the differential effects of gravitational stress, compression therapy and leg elevation on local inflammation.
To this end, the levels of three inflammatory biomarkers (matrix metalloproteinases, annexin V, microparticles) were measured in healthy subjects and CVI patients following three separate conditions: standing without compression, standing with compression, and lying without compression.
Participants
14 healthy subjects (C0-1, “volunteers”) and 14 patients with advanced CVI (C4a-b, “patients”) were enrolled in the study.
Abbreviations
- AV: annexin V
- CVI: chronic venous insufficiency
- MCS: medical compression stockings
- MiPa: microparticles
- MMP: matrix metalloproteinases